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Burn injury victims and bone metabolism findings

Washington residents should be aware that severe burn injury can cause changes in bone metabolism. These injuries can compromise the quality and structure of the bone, leading to other serious issues. While little is known about this connection, researchers have found that elevated bone turnover causes different biomechanical alterations in the skeleton.

One study evaluated 32 adult male patients who came into the ICU with severe injuries and burn trauma covering at least 20 percent of their bodies. Researchers found that there were significant differences in bone metabolism regulators and turnover markers during the course of the study. The changes observed suggest that alterations in bone metabolism have a negative impact on the structure and bone quality of burn injury victims.

In the early phase of the study, participants showed increases in certain markers, including procollagen type 1 N-terminal propeptide, sclerostin, bone-specific alkaline phosphate and fibroblast growth factor 23. There were also changes in levels of osteoprotegerin and phosphate. The prolonged phase of testing showed significant increases in P1NP, sclerostin, BALP and albumin, among others. There were also decreases in FGF23 and phosphate, along with several other levels. This research demonstrates a rapid change in bone resorption markers among adult male participants.

Victims of severe burn injuries may face long-term medical issues, not only from their injuries but from the compromised bone structure that can result. A personal injury lawyer can often assist one who was injured due to the negligent actions of another person in seeking compensation for ongoing medical and rehabilitation expenses as well as wages that were lost due to an inability to regain employment.

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